We are interested in understanding novel pathways that regulate tolerance, how these are dysregulated in autoimmunity, and what therapies may restore immune homeostasis. We take a multidisciplinary approach that brings together genetics, chemistry, computational and clinical collaborators to highlight disease-relevant biology. A major interest of the lab is understanding the mechanistic basis of immune dysregulation in people with Down syndrome, and leveraging these efforts to identify novel therapies that may benefit both people with Down syndrome as well as people with other immune disorders. Key ongoing interests center around how aging, autoimmunity and vaccine response is dysregulated in the setting of Down syndrome.
We are also working to better understand novel druggable regulators of T cell differentiation that we identified, including DYRK1A and CDK8. Inhibition of these kinases promises to reveal novel therapeutic modalities for autoimmunity.
Please contact Bernard directly if you're interested in joining the lab. The Khor lab is a high-mentoring, high-striving environment where trainees take creative, rigorous and multidisciplinary approaches to clinically relevant problems.